R. F. Schwabe

Conditional deletion of CEACAM1 causes hepatic stellate cell activation

This study shows that CEACAM1 loss in hepatic stellate cells (HSCs) activates them, leading to myofibroblastic transformation and fibrosis without insulin resistance or steatosis.

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Nuclear HMGB1 protects from non-alcoholic fatty liver diseases through negative regulation of liver X receptor

This study shows that nuclear HMGB1 suppresses liver lipogenesis in NAFLD by inhibiting LXR activity, preventing steatosis and insulin resistance.

Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenes.

This study shows that HMGB1 from leukocytes is critical for immune responses against Listeria monocytogenes, while hepatocyte HMGB1 is not essential for moderate infections but may contribute to excessive inflammation in severe cases.