Author

S. L. Friedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Yu· 2 shared D. Bhattacharya· 2 shared H. Chen· 2 shared M. Puchowicz· 2 shared P. Ranea-Robles· 2 shared S. Houten· 2 shared B. D. Brown· 1 shared B. Stauffer· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

C. Yu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Conditional deletion of CEACAM1 causes hepatic stellate cell activation

H. T. Muturi, H. E. Ghadieh, S. Asalla, S. G. Lester, S. Verhulst, H. L. Stankus, S. Zaidi, R. Abdolahipour, G. D. Belew, L. A. v. Grunsven, S. L. Friedman, R. F. Schwabe, T. D. Hinds, S. M. Najjar

This study shows that CEACAM1 loss in hepatic stellate cells (HSCs) activates them, leading to myofibroblastic transformation and fibrosis without insulin resistance or steatosis.

bioRxiv · Apr 2, 2024 · PreprintPhysiology

Mannose Supplementation Curbs Liver Steatosis and Fibrosis in Murine MASH by Inhibiting Fructose Metabolism

J. Hong, Y. Carbajal, J. Trotman, M. Glass, V. Sclar, I. L. Alter, P. Zhang, L. Wang, L. Chen, M. Petitjean, S. L. Friedman, C. DeRossi, J. Chu

This study shows that mannose reduces liver steatosis and fibrosis in MASH by inhibiting fructose metabolism, offering a potential therapeutic approach.

bioRxiv · Jan 17, 2024 · PreprintCell Biology

Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling

V. Q.-H. Trinh, T.-F. Lee, S. Lemoinne, K. C. Ray, M. D. Ybanez, T. Tsuchida, J. K. Carter, J. Agudo, B. D. Brown, K. M. Akat, S. L. Friedman, Y. A. Lee

This study shows hepatic stellate cells promote midlobular hepatocyte proliferation and metabolic zonation by secreting neurotrophin-3.

bioRxiv · Mar 3, 2023 · PreprintCell Biology

Secreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells

S. Merali, C. Quinn, C. Merali, M. C. Rico, J. Karanicolas, O. Perez-Leal, V. Mischley, S. L. Friedman

This study identifies secreted folate receptor-gamma (FOLR3) as a driver of fibrogenesis in NASH by enhancing TGFβ signaling in hepatic stellate cells.

bioRxiv · Jul 21, 2022 · PreprintBiochemistry

The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism

P. Ranea-Robles, H. Chen, B. Stauffer, C. Yu, D. Bhattacharya, S. L. Friedman, M. Puchowicz, S. Houten

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

bioRxiv · Jul 26, 2021Physiology

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis

P. Ranea-Robles, S. Violante, C. Argmann, T. Dodatko, D. Bhattacharya, H. Chen, C. Yu, S. L. Friedman, M. Puchowicz, S. Houten

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

bioRxiv · Mar 2, 2021Physiology