Cancer BiologybioRxivPreprint
STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia
T. Suske, H. Sorger, F. Ruge…·R. Moriggl
This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.
DOI 10.1101/2022.12.21.519945