B. Maurer

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

This paper creates a mouse model with a STAT5BN642H mutation to study NK-cell leukemia and finds it leads to both indolent and aggressive forms of the disease.

A modular and flexible open source cell incubator system for mobile and stationary use

The paper introduces a modular and flexible open-source cell incubator system for both mobile and stationary use, enabling customized incubation for diverse experimental needs.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

Murine ex vivo cultured alveolar macrophages provide a novel tool to study tissue-resident macrophage behavior and function

This paper introduces a method to culture and expand murine alveolar macrophages ex vivo over several months, showing they retain key features and functions.

A cutting-edge approach unravels a novel role for CDK6 in leukemic progenitor cells

This paper introduces a method to generate HPCLSK cells that mimic hematopoietic/leukemic progenitor cells and shows CDK6's role in leukemia formation and homing.

The neonatal microenvironment programs conventional and intestinal Tbet+ γδT17 cells through the transcription factor STAT5

This study shows STAT5 is critical for neonatal expansion of γδT17 cells, which acquire tissue-specific traits necessary for immunity and autoimmunity.