Author

A. T. Look

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. W. Zimmerman· 3 shared A. Berezovskaya· 2 shared A. D. Durbin· 2 shared B. J. Abraham· 2 shared H. Shi· 2 shared N. Prutsch· 2 shared R. Young· 2 shared S. He· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

M. W. Zimmerman

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4 papers

Recent·Most cited

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

N. Weichert-Leahey, H. Shi, T. Tao, D. Oldridge, A. Durbin, B. Abraham, M. Zimmerman, S. Zhu, A. Wood, D. Reyon, J. K. Joung, R. Young, S. J. Diskin, J. Maris, A. T. Look

The paper identifies a regulatory polymorphism in LMO1 that reduces neuroblastoma risk by preventing the adrenergic cell state in zebrafish and humans.

bioRxiv · Feb 28, 2023Cancer Biology

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

T. Suske, H. Sorger, F. Ruge, N. Prutsch, M. W. Zimmerman, T. Eder, B. Maurer, C. Wagner, S. Schoenefeldt, K. Spirk, A. Pichler, T. Pemovska, C. Schweicker, D. Poeloeske, D. Jungherz, , R. Moriggl

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

bioRxiv · Dec 21, 2022 · PreprintCancer Biology

STAT3 cooperates with the core transcriptional regulatory circuitry to drive MYC expression and oncogenesis in anaplastic large cell lymphoma

N. Prutsch, S. He, A. Berezovskaya, A. D. Durbin, N. V. Dharia, K. Stegmaier, J. D. Matthews, L. Hare, S. D. Turner, L. Kenner, O. Merkel, R. A. Young, B. J. Abraham, A. T. Look, M. W. Zimmerman

This study identifies STAT3's role in driving MYC expression and oncogenesis in ALCL by cooperating with a core transcriptional regulatory circuit.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

Retinoic acid rewires the adrenergic core regulatory circuitry of neuroblastoma

M. W. Zimmerman, A. D. Durbin, S. He, F. Oppel, H. Shi, T. Tao, Z. Li, A. Berezovskaya, Y. Liu, J. Zhang, R. Young, B. J. Abraham, A. T. Look

This study shows retinoic acid reprograms enhancer landscapes in MYCN-amplified neuroblastoma cells, downregulating MYCN and inducing sympathetic differentiation.

bioRxiv · Jul 23, 2020Cancer Biology