Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype
H. Tagoe, S. Hassan, G. Youssef, K. Mills, J. Harper, R. F. O'Shaughnessy
This study identifies TLR2 activation as a common mechanism in ichthyosis, showing it induces hyperkeratosis and alters keratin expression through NFκB and Gata3 pathways.
bioRxiv · Jun 6, 2022Cell Biology