S. Hassan

Low-Cost Robotic Manipulation of Live Microtissues for Cancer Drug Testing

This paper presents a low-cost robotic platform for manipulating live microtissues to enable cancer drug testing using patient biopsies on 384-well plates.

Perception and Readiness Towards Inter-Professional Education Among Different Health Care Disciplines at Khyber Medical University Peshawar

This study assesses perception and readiness towards interprofessional education among healthcare students at Khyber Medical University, finding strong positive correlations between perception and readiness.

Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype

This study identifies TLR2 activation as a common mechanism in ichthyosis, showing it induces hyperkeratosis and alters keratin expression through NFκB and Gata3 pathways.

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

The paper shows that a conserved Asp residue in BRICHOS domains is critical for inhibiting amyloid toxicity but not amorphous aggregation, with pH sensitivity and evolutionary conservation.

Sugar Beet Extract Acts as a Natural Bio-Stimulant for Physio-Biochemical analysis of Hordeum Vulgare L. under Induced Salinity Stress

This study evaluates sugar beet extract's ability to mitigate salinity stress effects on barley growth and physiological traits.

Plasmodium falciparum protein Pfs16 is a target for transmission-blocking antimalarial drug development

This study identifies Pfs16 as the cellular target of the N-4HCS compound DDD01035881, which blocks Plasmodium male gamete formation.

An assessment of efficacy of Iodine complex (Renessans) against SARS-CoV-2 in non-human primates (Rhesus macaque)

This study evaluates the efficacy of Renessans, an iodine complex, against SARS-CoV-2 in Rhesus macaques, showing reduced viral load and faster clearance in treated groups.

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

This study identifies a small-molecule amyloid inhibitor that disrupts mutant p53 aggregation, restores its function, and reduces tumor growth in xenograft models.

Intermittent hormonal therapy shows similar outcome than SOC in ER+ breast cancer preclinical model.

This study shows intermittent hormonal therapy achieves similar tumor control as standard-of-care in ER+ breast cancer models with reduced drug use and preserved sensitive cell phenotypes.