A self-inactivating invertebrate opsin with resistance to retinal depletion optically drives biased signaling toward Gβγ-dependent ion channel modulation
This paper introduces a self-inactivating invertebrate opsin that preferentially activates Gβγ-dependent ion channels over Ga-dependent pathways, enabling light-controlled biased signaling.
bioRxiv · Jan 5, 2023 · PreprintBiophysics