Y. Kubo

Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist

This study identifies BD1047 as a direct inhibitor of GIRK channels, showing stronger inhibition of GIRK4 than GIRK2 and revealing structural determinants involving Leu77 on GIRK4.

Genetic basis of lineage-specific evolution of fruit traits in hexaploid persimmon

The paper identifies loci associated with fruit traits in hexaploid persimmon using genome-wide association analysis, finding no overlap with regions under selective sweep.

A self-inactivating invertebrate opsin with resistance to retinal depletion optically drives biased signaling toward Gβγ-dependent ion channel modulation

This paper introduces a self-inactivating invertebrate opsin that preferentially activates Gβγ-dependent ion channels over Ga-dependent pathways, enabling light-controlled biased signaling.

Conformational rearrangements in 2nd voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels

This study shows that conformational changes in the voltage-sensor domain of TPCs determine whether they are PIP2- or voltage-gated, and that these modes can be switched by small molecules.

A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K+ channel

This study identifies a novel ion-conducting pathway in a GIRK channel mutant, showing it allows Li+ permeation independent of the selectivity filter.

Genome-wide cis-decoding for expression designing in tomato using cistrome data and explainable deep learning

This study uses cistrome data and explainable deep learning to predict tomato fruit expression patterns from DNA sequences, identifying key regulatory elements involved in ripening.

Intrinsic Gating Behavior of Voltage-Gated Sodium Channels Predetermines Regulation by Auxiliary β-subunits

This study shows that the intrinsic movement order of voltage-sensing domains in Nav channels determines their susceptibility to regulation by β1 and β3 subunits, explaining variable regulatory effects across channel isoforms.

Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

The paper uses voltage-clamp fluorometry to study structural changes in P2X2 channels during voltage-dependent gating, identifying key interactions and electric field effects.

Arabidopsis SMN2/HEN2, encoding DEAD-box RNA helicase, governs proper expression of the resistance gene SMN1/RPS6 and is involved in dwarf, autoimmune phenotypes of mekk1 and mpk4

This study identifies SMN2/HEN2 as a regulator of SMN1/RPS6 expression and its role in plant immunity, showing its involvement in dwarf and autoimmune phenotypes in mekk1 and mpk4 mutants.

Low temperature transcriptionally modulates natural peel degreening in lemon (Citrus limon L.) fruit independently of endogenous ethylene

The paper investigates how low temperature promotes peel degreening in lemon fruit through gene regulation, independent of ethylene, by analyzing transcriptome changes and physiological responses.

CAT1/SLC7A1 acts as a cellular receptor for bovine leukemia virus infection

This paper identifies CAT1/SLC7A1 as the cellular receptor for bovine leukemia virus (BLV) infection, showing it mediates viral entry and is essential for BLV susceptibility across species.