Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2
A. A. Kawale, J. M. Taliaferro, H.-S. Kang, C. Hartmueller, A. Geerlof, R. Stehle, C. Burge, D. C. Rio, M. Sattler
The paper determines the structure of the Drosophila LS2 protein's RRM domains and shows they interact with G quadruplex RNA motifs to regulate alternative splicing.
bioRxiv · Aug 15, 2020 · PreprintBiochemistry