An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus
A. Navickas, H. Asgharian, J. Winkler, L. Fish, K. Garcia, D. Markett, M. Dodel, B. Culbertson, S. Miglani, T. Joshi, P. Nguyen, S. Zhang, N. Stevers, H.-W. Hwang, F. Mardakheh, , H. Goodarzi
The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.
bioRxiv · Oct 4, 2021Cancer Biology