H. Goodarzi

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

This study identifies ENPP1 as an innate immune checkpoint that suppresses the cGAMP-STING pathway, promoting tumor growth and metastasis, and shows that inhibiting its cGAMP hydrolase activity enhances cancer immunity.

Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis

The paper identifies gene networks driving cancer progression by analyzing stem-cell states in mouse skin carcinogenesis and links them to drug resistance and immune surveillance in human tumors.

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

This study identifies non-coding regulatory regions driving metastatic prostate cancer using an integrative computational and experimental approach.

Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes

This study uses computational drug repositioning to identify agents that can sensitize drug-resistant breast tumors, finding fulvestrant effective across multiple treatment and receptor subtypes.

Propagated circulating tumor cells uncovers the rople of NFκB and COP1 in metastasis

This study develops a CTC and CDX platform to expand patient-derived CTCs and identifies NFκB and COP1 as drivers of metastasis.

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

Functional microRNA-Targeting Drug Discovery by Graph-Based Deep Learning

This study develops RiboStrike, a deep learning framework to identify small molecules targeting microRNAs, demonstrating its effectiveness in finding anti-miR-21 compounds with cancer therapeutic potential.

Zebrafish xenografts to isolate unique human breast cancer metastatic cell populations

This paper develops a zebrafish xenograft model to isolate and study human breast cancer metastatic cells, identifying genes and pathways involved in invasion.

A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

A systematic comparison of fibroblasts derived from postmortem human dura mater versus dermal epithelium for neurodegenerative disease modeling

This study compares fibroblasts from postmortem human dura mater and dermal epithelium, finding significant differences in morphology, growth, marker expression, and chromosomal abnormalities.

Two Isoleucyl tRNAs that Decode 'Synonymous' Codons Divergently Regulate Breast Cancer Progression

The paper shows that two isoleucyl tRNAs decode synonymous codons and have opposing effects on breast cancer progression by regulating translation of growth-promoting genes.

C/EBPB-dependent Adaptation to Palmitic Acid Promotes Stemness in Hormone Receptor Negative Breast Cancer

The paper shows obesity-induced palmitic acid drives tumor initiation in hormone receptor negative breast cancer through C/EBPB-dependent transcriptional networks.

Androgen regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

This study shows androgen signaling increases ACE2 levels, contributing to severe COVID-19 in men, and suggests androgen receptor inhibition as a potential treatment.

PCK1 and DHODH drive colorectal cancer liver metastatic colonization and nucleotide biosynthesis under hypoxia

This study identifies PCK1 and DHODH as drivers of colorectal cancer liver metastasis under hypoxia by promoting nucleotide biosynthesis.