J. Winkler

A sensorimotor enhanced neuromusculoskeletal model for simulating postural control of upright standing

This paper introduces a neuromusculoskeletal model for simulating upright standing postural control using sensor feedback, showing it can replicate physiological joint movements and reactive balance behavior.

Spatio-temporal analysis of Vaccinia virus infection and host response dynamics using single-cell transcriptomics and proteomics

This study uses single-cell transcriptomics and proteomics to analyze Vaccinia virus infection dynamics and host response heterogeneity in HeLa and fibroblast cells.

RNA splicing modulator induces peripheral neuropathy with increased neurofilament light chain levels via p53 signaling

This paper shows that the RNA splicing modulator branaplam causes peripheral neuropathy by activating p53 signaling, leading to increased neurofilament light chain levels in motor neurons.

The temporal progression of immune remodeling during metastasis.

This paper uses longitudinal scRNA-seq to study immune changes in lung metastasis, identifying inflammatory programs and signaling networks associated with metastatic progression.

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

This study analyzes single-cell transcriptomes of primary tumors and metastases from breast cancer models, identifying transcriptional differences and gene signatures linked to metastatic potential and patient outcomes.

Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants

This study shows that AtEH1 and AtEH2 subunits of the TPC complex drive biomolecular condensation to facilitate clathrin-mediated endocytosis in plants, with their disordered regions regulating condensate properties and endocytosis dynamics.

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

Combinatorial immunotherapies overcome MYC-driven immune evasion

This study shows that MYC-driven immune evasion in TNBC can be reversed by combining immunotherapies, leading to tumor regression in mice.

The TPLATE subunit is essential for structural assembly of the endocytic TSET complex

The paper determines the structural architecture of the plant TSET complex and identifies key interactions essential for its assembly and function in endocytosis.

Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia

This study identifies redox and protein homeostasis as key factors in toxin-induced biliary atresia, showing that genetic modulation of these pathways affects cholangiocyte injury and suggesting potential therapeutic strategies.

Visualizing protein-protein interactions in plants by rapamycin-dependent delocalization

The paper introduces a conditional in vivo PPI tool for plants, KSP, which allows visualization of protein-protein interactions and complex multi-protein interactions using rapamycin-dependent delocalization.

Nanobody-dependent delocalization of endocytic machinery in Arabidopsis root cells dampens their internalization capacity

This study uses nanobody-dependent delocalization to reduce TPC function in Arabidopsis root cells, showing reduced endocytic flux without major growth effects.