Author

L. Fish

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. Goodarzi· 5 shared A. Navickas· 4 shared K. Garcia· 4 shared D. Markett· 3 shared H. Asgharian· 3 shared B. Culbertson· 2 shared A. Arab· 1 shared A. Goga· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersCancer Biology

H. Goodarzi

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5 papers

Recent·Most cited

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

A. Y. Ge, A. Arab, R. Dai, A. Navickas, L. Fish, K. Garcia, H. Asgharian, J. Goudreau, S. Lee, K. Keenan, M. B. Pappalardi, M. T. McCabe, L. Przybyla, H. Goodarzi, L. Gilbert

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Scientific Reports · Oct 29, 2024Peer-reviewedCancer Biology

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

J. Wang, J. M. Suh, B. J. Woo, A. Navickas, K. Garcia, K. Yin, L. Fish, T. Cavazos, B. Hanisch, D. Markett, S. Yu, G. Hirst, L. Brown-Swigart, L. J. Esserman, L. J. van 't Veer, H. Goodarzi

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

bioRxiv · Mar 19, 2024Cancer Biology

RPL22 is a tumor suppressor in MSI-high cancers and a key splicing regulator of MDM4

H. N. W. Weinstein, K. Hu, L. Fish, Y.-A. Chen, P. Allegakoen, K. S. F. Hui, J. H. Pham, M. B. Baco, H. Song, A. O. Giacomelli, F. Vazquez, M. Ghandi, H. Goodarzi, F. W. Huang

This study identifies RPL22 as a tumor suppressor in MSI-H cancers that regulates MDM4 splicing and reveals its role in oncogenic pathways.

bioRxiv · Dec 10, 2023Cancer Biology

A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

B. Culbertson, K. Garcia, D. Markett, H. Asgharian, L. Chen, L. Fish, A. Navickas, J. Yu, B. Woo, S. Nanda, J. Rabinowitz, H. Goodarzi

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

bioRxiv · Oct 8, 2021Cancer Biology

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

A. Navickas, H. Asgharian, J. Winkler, L. Fish, K. Garcia, D. Markett, M. Dodel, B. Culbertson, S. Miglani, T. Joshi, P. Nguyen, S. Zhang, N. Stevers, H.-W. Hwang, F. Mardakheh, , H. Goodarzi

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

bioRxiv · Oct 4, 2021Cancer Biology