Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility
S.-J. Shin, B. Bayarkhangai, K. Tsogtbaataar, M. Yuxuan, S.-H. Kim, Y.-J. Kim, D. Kim, D.-H. Kim, J.-H. Lee, J. Hyun, H.-W. Kim
This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.
bioRxiv · Feb 13, 2024Bioengineering