Y.-J. Kim

Matrix-rigidity cooperates with biochemical cues in M2 macrophage activation through increased nuclear deformation and chromatin accessibility

This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.

Sequential genetic, epigenetic alterations in human pluripotent stem cells for recurrent abnormality

The paper investigates genetic and epigenetic changes in human pluripotent stem cells during in vitro culture and identifies 20q11.21 copy number gain and epigenetic modifications as key factors in inducing culture-adapted phenotypes.

Th17 cells target the metabolic miR-142-5p-SDHC/SDHD axis promoting invasiveness and progression of cervical cancers

This study identifies a Th17 cell-driven miR-142-5p-SDHC/SDHD axis that enhances cervical cancer migration and invasion, with clinical correlations to metastasis and survival.

Synthetic lipid rafts formed by cholesterol nano-patch induce early T cell activation

This study uses cholesterol nano-patches to show that spatial cholesterol arrangement induces early T cell activation by forming synthetic lipid rafts and reorganizing signaling molecules.

Discovery and pre-clinical evaluation of antibodies to the NKG2A inhibitory receptor

The paper discovers and evaluates two fully human antibodies that inhibit NKG2A, an inhibitory receptor on NK and CD8+ T cells, enhancing anti-cancer immune responses.

Inhibitors of anti-apoptotic Bcl-2 family proteins exhibit potent and broad-spectrum anti-mammarenavirus activity via cell cycle arrest at G0/G1 phase

This paper shows Bcl-2 inhibitors like ABT-737 and OLX block mammarenavirus and SARS-CoV-2 by causing G0/G1 cell cycle arrest, not through apoptosis.

TPX2 Amplification-Driven Aberrant Mitosis in Long-Term Cultured Human Embryonic Stem Cells

The paper identifies TPX2 amplification in late-passaged hESCs as a driver of mitotic aberrations through transcriptome and genomic analysis.

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.

Differential risk of incident cancer in patients with heart failure: A nationwide population-based cohort study

This study finds that patients with heart failure have a higher risk of developing cancer compared to the general population, with increased risk observed across multiple cancer types.