Cancer cell-autonomous cGAS-STING response confers drug resistance
Q.-M. Lv, S.-Y. Wang, H.-M. Lei, K.-R. Zhang, Y.-B. Tang, Y. Shen, L.-M. Lu, H.-Z. Chen, L. Zhu
This study shows that cGAS-STING signaling in cancer cells promotes drug resistance by responding to cytosolic DNA from chemotherapy, suggesting caution in combining STING agonists with chemotherapy.
bioRxiv · Oct 23, 2021Cancer Biology