A single-cell genetic colocalization test improves power and resolves disease-mediating cell types
Jonathan Mitchel, Sumaiya Nazeen, Xinyuan Wang, Praveen K. Patnaik, Autumn Rose Morrow, Habib Nasir, Ronya Strom, Dylan Ritter, Lorenz Studer, Sung Chun, Chris J. Cotsapas, Vikram Khurana, Peter V. Kharchenko, Shamil R. Sunyaev
The paper introduces scJLIM, a cluster-free method for single-cell colocalization testing, improving power to link GWAS loci with gene expression changes in specific cell types.
bioRxiv · Oct 10, 2025 · PreprintGenomics