Praveen K. Patnaik

A single-cell genetic colocalization test improves power and resolves disease-mediating cell types

The paper introduces scJLIM, a cluster-free method for single-cell colocalization testing, improving power to link GWAS loci with gene expression changes in specific cell types.

Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

This paper shows that manipulating intracellular ATP levels in yeast through synthetic ATP import extends cellular lifespan and reveals distinct metabolic pathways involved in aging.

Genome-wide ribosome profiling uncovers the role of iron in the control of protein translation

The paper uses ribosome profiling to show how iron deficiency affects protein translation in yeast by altering gene expression and RNA-binding protein activity.

Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function

The paper shows that reducing Cth2 activity in yeast increases lifespan by improving mitochondrial function through reduced repression of iron-related genes.