Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution
Ruiying Ma, Muwon Kang, Gyu Hyun Kim, Hyojin Kang, Sunho Lee, Yeji Yang, Hae Ji Lee, Seungji Choi, Seungsoo Kim, Seoyeong Kim, Yukyung Jun, Hyewon Kim, Yinhua Zhang, U Suk Kim, Hyae Rim Kang, , Kihoon Han
This study uses longitudinal multi-omic analyses of a mouse model to show seizure evolution in West syndrome involves synaptic remodeling, gliosis, and proteomic/lipidomic changes over time.
bioRxiv · May 6, 2025 · PreprintNeuroscience