Hyewon Kim

Imbalance between RNA-binding proteins and the WAVE regulatory complex underlies the toxic gain-of-function effects of the CYFIP2 Arg87Cys variant in neurodevelopmental disorders

Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution

This study uses longitudinal multi-omic analyses of a mouse model to show seizure evolution in West syndrome involves synaptic remodeling, gliosis, and proteomic/lipidomic changes over time.

Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number

The paper demonstrates that dimensionality scales unboundedly with neuron number in mouse cortex-wide recordings, revealing internal variables without immediate behavioral correlates.

Passive Exposure Sparsifies Neural Activity in the Primary Visual Cortex

The paper shows that passive exposure to images increases sparseness in primary visual cortex neural activity by reducing responses of less active neurons.

High-Speed, Cortex-Wide Volumetric Recording of Neuroactivity at Cellular Resolution using Light Beads Microscopy

This paper introduces Light Beads Microscopy (LBM), a high-speed volumetric imaging technique for neuroactivity, demonstrating cellular resolution recordings in mouse cortex at speeds compatible with calcium transient resolution.