Seungsoo Kim

This study identifies UBE3C as a longevity-associated E3 ligase that maintains nuclear lamina integrity by modulating LMNB1 and LBR through selective autophagy, delaying senescence.

The paper identifies rare longevity-associated variants, including a cGAS mutation, in long-lived families and shows they reduce inflammation and delay cellular senescence.

This study identifies Hedgehog signaling as a key driver of intestinal stem cell regeneration by promoting the emergence of new Lgr5+ stem cells from non-Lgr5+ clones, distinct from existing self-renewal and dedifferentiation models.

This study uses longitudinal multi-omic analyses of a mouse model to show seizure evolution in West syndrome involves synaptic remodeling, gliosis, and proteomic/lipidomic changes over time.

This study shows that PNMA1 and PNMA4, derived from retrotransposons, are essential for reproductive capacity, as their absence leads to subfertility and hormonal changes in mice and associations with reproductive traits in humans.

The paper identifies candidate regulators of LINE-1 RNA levels in lymphoblastoid cells using eQTL analysis and validates some candidates experimentally.

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

The paper identifies a longevity-associated SMAD3 non-coding variant that impairs a cell-type specific enhancer, reducing inflammation and senescence in endothelial cells and improving healthspan in a mouse model.

This paper shows that polygenic risk scores (PRS) overestimate predictive accuracy when datasets have overlapping subjects, using Alzheimer's disease and other traits as examples.

This study analyzes genetic variants associated with longevity and age-related diseases to understand their impact on gene expression.