Eunjoon Kim

The paper uses an AI-driven framework to model perturbations in brain organoids and identifies candidate genes for autism using genomic and clinical data.

The paper shows that the SHANK3-CAMSAP2 interaction links synapses to dendritic microtubule organisation in parvalbumin neurons, with the SHANK3L68P mutation enhancing this interaction and altering microtubule dynamics.

This study uses longitudinal multi-omic analyses of a mouse model to show seizure evolution in West syndrome involves synaptic remodeling, gliosis, and proteomic/lipidomic changes over time.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

This study identifies brain region-specific changes and dopamine dysregulation in Grin2a mutant mice, supporting schizophrenia hypotheses and highlighting their utility as a genetic model.

This study examines neuronal firing patterns in IRSp53-mutant mice during social approach, finding reduced variability and impaired social information encoding in the medial prefrontal cortex.

This study shows that enhanced negative emotional processing in Shank2-KO mice impairs reversal learning, suggesting a link between emotional processing and behavioral flexibility in ASD.

This study shows two ASD-associated SHANK3 mutations cause structural changes and altered protein turnover at synapses.

The paper identifies noncoding de novo mutations contributing to autism spectrum disorder by altering chromatin interactions and gene expression in neural stem cells.

The paper identifies protein-protein interactions on Chr21 linked to intellectual disabilities, autism, and Alzheimer's by analyzing yeast two-hybrid screens and synaptic localization.

This study investigates the role of SALM1/LRFN2 in synaptic function and behavior by analyzing Lrfn2-/- mice, finding altered synaptic plasticity, inhibitory synapse development, and social communication behaviors.