Complement 3a Receptor mediates high fat diet induced hypothalamic accumulation of lipid associated microglia to regulate neuroinflammation and obesity
Jean Pierre Pallais, Maria Razzoli, Pedro Rodriguez, Audrey L. Daugherty, Seth McGonigle, Bianca Vezzani, Hannah Hillman, Luca Verteramo, Patricia R. Schrank, Preethy Parthiban, Xuechun Chang, Haiguang Wang, Colleen L. Forster, Carmen Nanclares, Gianluigi Veglia, , Alessandro Bartolomucci
This study identifies C3aR as a mediator of HFD-induced hypothalamic microgliosis and obesity, showing its role in lipid droplet formation and neuroinflammation.
Journal of Neuroinflammation · Oct 1, 2026Peer-reviewedImmunology