Alfonso Araque

This study identifies C3aR as a mediator of HFD-induced hypothalamic microgliosis and obesity, showing its role in lipid droplet formation and neuroinflammation.

This study identifies CK2 as a regulator of tauopathy by modulating tau phosphorylation, neuroinflammation, and synaptic dysfunction in mice.

The paper identifies a spatial threshold for astrocyte calcium signal propagation in mice, which determines gliotransmitter release and synaptic modulation.

This study identifies aberrant astrocytic calcium signaling in MS models as a contributor to synaptic plasticity impairment and gray matter pathology.

The paper shows that two endocannabinoids, 2-AG and AEA, signal to different cell types (neurons and astrocytes), inducing distinct synaptic regulation mechanisms.

This study shows that altered calcium signaling in Bergmann glia contributes to the electrophysiological changes in Purkinje cells in SCA1 mice, suggesting a therapeutic target for treatment.

The paper reveals column- and layer-specific astrocyte-mediated non-synaptic communication between cortical neurons through CB1R activation and ATP/adenosine release.

This study shows that reducing CK2 in HD mice improves neuroinflammation, HTT aggregation, and motor deficits by reducing synucleinopathy.

This study shows that IGF-I signaling in astrocytes regulates inhibitory synaptic plasticity and behavior by inducing LTD through ATP/adenosine release and A2A receptor activation.