Daniele Lettieri‐Barbato

Complement 3a Receptor mediates high fat diet induced hypothalamic accumulation of lipid associated microglia to regulate neuroinflammation and obesity

This study identifies C3aR as a mediator of HFD-induced hypothalamic microgliosis and obesity, showing its role in lipid droplet formation and neuroinflammation.

TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium

This study shows TREM2 drives pro-scarring macrophage accumulation in infarcted myocardium, leading to fibrosis and reduced cardiac repair.

Primary Hyperparathyroidism Reveals Limited Adipose Remodeling in Human

This paper investigates the effects of chronic PTH excess in PHPT on adipose tissue in humans and finds no significant thermogenic or energy-dissipating changes, but identifies a selective secretory phenotype.

MACanalyzeR: scRNA-seq Analysis Tool Reveals PPARγHI Lipid-Associated Macrophages Facilitate Thermogenic Expansion in BAT

The paper introduces MACanalyzeR, a scRNA-seq tool, to identify PPARγ-high lipid-associated macrophages in BAT that support thermogenic expansion.

Brown Adipose Tissue undergoes pathological perturbations and shapes C2C12 myoblast homeostasis in the SOD1-G93A mouse model of Amyotrophic Lateral Sclerosis.

The paper investigates changes in brown adipose tissue and its extracellular vesicles in an ALS mouse model, showing their impact on myoblast homeostasis and muscle atrophy.