Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner
Liana Senaldi, Nora Ali Hassan, Sean M. Cullen, Uthra Balaji, Natalie A. Trigg, Jinghua Gu, Hailey Finkelstein, Kathryn L. Phillips, Colin C. Conine, Matthew Smith-Raska
The paper shows that a mutation in Khdc3 in ancestral mice leads to transgenerational metabolic defects in offspring through epigenetic changes in gametes.
bioRxiv · Feb 27, 2024 · PreprintGenetics