Author

Jinghua Gu

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Uthra Balaji· 2 shared Alper EroğluiD· 1 shared Andrew F. NeuwaldiD· 1 shared Asa ThibodeauiD· 1 shared Asunción MejíasiD· 1 shared Chris P. VerschooriD· 1 shared Colin C. ConineiD· 1 shared Derya UnutmaziD· 1 shared

Activity by Year

2015-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Uthra Balaji

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures

Djamel Nehar-Belaid, Asa Thibodeau, Alper Eroğlu, Radu Marcheş, Giray Naim Eryilmaz, Titas Grabauskas, Luke Trinity, Derya Unutmaz, Chris P. Verschoor, Jinghua Gu, Uthra Balaji, Asunción Mejías, Virginia Pascual, George A. Kuchel, Octavio Ramilo, , Duygu Ucar

The paper maps the human immune system across the lifespan using scRNA-seq and snATAC-seq, revealing unique infant immune signatures and age-related changes in immune cell populations.

Nature Communications · Jun 15, 2026Peer-reviewedImmunology

Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

Liana Senaldi, Nora Ali Hassan, Sean M. Cullen, Uthra Balaji, Natalie A. Trigg, Jinghua Gu, Hailey Finkelstein, Kathryn L. Phillips, Colin C. Conine, Matthew Smith-Raska

The paper shows that a mutation in Khdc3 in ancestral mice leads to transgenerational metabolic defects in offspring through epigenetic changes in gametes.

bioRxiv · Feb 27, 2024 · PreprintGenetics

BICORN: An R package for integrative inference of de novo cis-regulatory modules

Xi Xian Chen, Jinghua Gu, Andrew F. Neuwald, Leena A Hilakivi-Clarke, Robert C. Clarke, Jianhua Xuan

BICORN integrates transcription factor binding and gene expression data to infer sparse cis-regulatory modules and their regulatory networks.

Scientific Reports · May 14, 2020Peer-reviewedBioinformatics

Sphinx: modeling transcriptional heterogeneity in single-cell RNA-Seq

Jinghua Gu, Qiumei Gu, Xuan Wang, Pingjian Yu, Wei Lin

The paper introduces a model to detect changes in transcriptional heterogeneity using burst proportion and magnitude, validated by RNA-FISH.

bioRxiv · Oct 1, 2015 · PreprintBioinformatics