Acetylation of lysine 82 initiates TDP-43 nuclear loss of function by disrupting its nuclear import
Sitao Zhang, Sonia Vazquez‐Sanchez, Shan Lu, Michael W. Baughn, Jaisen Lim, Spencer Oung, Lilian Gao, Jolene K. Diedrich, John R. Yates, Haiyang Yu, John Ravits, Don W. Cleveland
This study identifies acetylation of lysine 82 in TDP-43 as a mechanism causing nuclear loss of function and cytoplasmic accumulation, linked to neurodegenerative diseases like ALS.
bioRxiv · Sep 4, 2024 · PreprintNeuroscience