Author

Michael W. Baughn

University of California San DiegoORCID 0000-0001-8525-8024Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Don W. ClevelandiD· 2 shared Aaron A. SmargoniD· 1 shared Deepak PantiD· 1 shared Dominic Paul LeeiD· 1 shared Esaul Garcia· 1 shared Gene Wei-Ming YeoiD· 1 shared Haiyang Yu· 1 shared Harriet Mak· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Don W. ClevelandORCID

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2 papers

Recent·Most cited

Dual-targeting snRNA gene therapy rescues STMN2 and UNC13A splicing in TDP-43 proteinopathies

Trent A. Gomberg, Sara Elmsaouri, Hema Kopalle, Michael W. Baughn, Melinda S. Beccari, Melissa McAlonis‐Downes, Jonathan W. Artates, Deepak Pant, Harriet Mak, Aaron A. Smargon, Tynan C. Sander, Esaul Garcia, Dominic Paul Lee, Don W. Cleveland, Gene Wei-Ming Yeo

This study develops a gene therapy strategy using snRNAs to correct mis-splicing of STMN2 and UNC13A in TDP-43 proteinopathies, showing restoration of protein levels and axonal regeneration in motor neurons.

bioRxiv · Dec 3, 2025 · PreprintNeuroscience

Acetylation of lysine 82 initiates TDP-43 nuclear loss of function by disrupting its nuclear import

Sitao Zhang, Sonia Vazquez‐Sanchez, Shan Lu, Michael W. Baughn, Jaisen Lim, Spencer Oung, Lilian Gao, Jolene K. Diedrich, John R. Yates, Haiyang Yu, John Ravits, Don W. Cleveland

This study identifies acetylation of lysine 82 in TDP-43 as a mechanism causing nuclear loss of function and cytoplasmic accumulation, linked to neurodegenerative diseases like ALS.

bioRxiv · Sep 4, 2024 · PreprintNeuroscience