mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures
Alexander A. Cohen, Jennifer R. Keeffe, Lusineh Manasyan, Indeever Madireddy, Ange-Célia I Priso Fils, Kim-Marie A. Dam, Haley E. Stober, Rory A. Hills, Woohyun J Moon, Paulo J C Lin, Mark R. Howarth, Magnus A. G. Hoffmann, Pamela J. Björkman
This paper develops mRNA-based vaccines encoding RBD quartets and shows they match or improve antibody breadth, T-cell responses, and epitope targeting compared to protein-based vaccines.
Cell Reports · May 1, 2026Peer-reviewedImmunology