This paper introduces Duality vaccination, a method that delivers both activating and inhibitory stimuli to shape antibody responses, using nanoparticle-based immunogens.

bioRxiv · Oct 30, 2026 · PreprintSynthetic Biology

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 depends on presenting VP4 in a virus-like conformation

James T. Kelly, Giann Kerwin Y. Dellosa, Joseph Newman, Rory A. Hills, Adel A. M. Mohamed, S. L. Johnston, Sebastain L. Johnston, Tobias J. Tuthill

This study shows that presenting VP4 peptides in a virus-like conformation induces neutralising antibodies in mice, highlighting the importance of antigenic conformation for vaccine design.

PLoS Pathogens · Jul 16, 2026Peer-reviewedMicrobiology

mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures

Alexander A. Cohen, Jennifer R. Keeffe, Lusineh Manasyan, Indeever Madireddy, Ange-Célia I Priso Fils, Kim-Marie A. Dam, Haley E. Stober, Rory A. Hills, Woohyun J Moon, Paulo J C Lin, Mark R. Howarth, Magnus A. G. Hoffmann, Pamela J. Björkman

This paper develops mRNA-based vaccines encoding RBD quartets and shows they match or improve antibody breadth, T-cell responses, and epitope targeting compared to protein-based vaccines.

Cell Reports · May 1, 2026Peer-reviewedImmunology

Digitally immune optimised haemagglutinin with nanocage plug-and-display elicits broadly neutralising pan-H5 influenza subtype vaccine responses

Chloe Qingzhou Huang, Rory A. Hills, George Carnell, Sneha Vishwanath, Ernest T. Aguinam, Andrew C. Y. Chan, Phil Palmer, Laura O’Reilly, Paul Tonks, Nigel James Temperton, Simon D. W. Frost, Laurence S. Tiley, Mark R. Howarth, Jonathan Luke Heeney

This paper develops a vaccine candidate using DIOSvax-H5inter nanocages that elicits cross-clade neutralising antibodies and T cell responses against diverse H5 influenza strains.

Emerging Microbes & Infections · Jun 6, 2025Peer-reviewedImmunology