Alexander A. Cohen

Duality Vaccination through Nanodesign of Click-Ligated B-Cell Inhibitory Receptor Bridging

This paper introduces Duality vaccination, a method that delivers both activating and inhibitory stimuli to shape antibody responses, using nanoparticle-based immunogens.

mRNA delivery of mosaic-8 pan-sarbecovirus RBD vaccines elicits distinct antibody epitope signatures

This paper develops mRNA-based vaccines encoding RBD quartets and shows they match or improve antibody breadth, T-cell responses, and epitope targeting compared to protein-based vaccines.

Development of a Recombinant Single-Cycle Influenza Viral Vector as an Intranasal Vaccine against SARS-CoV-2 and SARS-like Betacoronaviruses

This paper develops a recombinant single-cycle influenza viral vector vaccine against SARS-CoV-2 and SARS-like betacoronaviruses, showing robust immune responses in mice.

Single administration of mosaic-8b RBD-nanoparticle vaccine prepared with atomic layer deposition technology elicits broadly neutralizing anti-sarbecovirus responses

This study evaluates ALD-delivered mosaic-8b RBD-nanoparticles, showing improved cross-reactive antibody responses against mismatched sarbecoviruses compared to conventional immunizations.

Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice

This study evaluates bivalent S-EABR mRNA-LNP boosters in pre-vaccinated mice, showing enhanced neutralizing responses and polyclass RBD antibody diversity against SARS-CoV-2 variants.

Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles

This paper develops mosaic RBD-nanoparticles to induce cross-reactive anti-sarbecovirus antibodies in animals, demonstrating their effectiveness against SARS-CoV-2 variants and zoonotic viruses.