Kim-Marie A. Dam

This paper develops mRNA-based vaccines encoding RBD quartets and shows they match or improve antibody breadth, T-cell responses, and epitope targeting compared to protein-based vaccines.

This study evaluates bivalent S-EABR mRNA-LNP boosters in pre-vaccinated mice, showing enhanced neutralizing responses and polyclass RBD antibody diversity against SARS-CoV-2 variants.

The paper identifies minimal somatic hypermutations required for CD4bs bNAb neutralization breadth and uses structural data to guide HIV-1 vaccine immunogen design.

The paper analyzes SARS-CoV-2 spike protein dynamics using eVLPs and HDX-MS, showing the D614G mutation and furin cleavage influence conformational states and infectivity.

The paper classifies neutralizing antibodies against SARS-CoV-2 spike RBD based on structure, identifying binding modes and implications for vaccine and therapeutic strategies.