Author

Haley Heine

Johns Hopkins University

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1

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Andrew S PekosziD· 1 shared Camille Wouters· 1 shared Haocheng WangiD· 1 shared Jiou WangiD· 1 shared Junqin Yang· 1 shared Mingming LiuiD· 1 shared Peixi Chang· 1 shared Qiwang XiangiD· 1 shared

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2026-2026 · peak 1/yr

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Andrew S PekoszORCID

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1 paper

Recent·Most cited

Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus

Qiwang Xiang, Camille Wouters, Peixi Chang, Yuning Lu, Mingming Liu, Haocheng Wang, Haley Heine, Sunning Qian, Junqin Yang, Andrew S Pekosz, Yan‐Jin Zhang, Jiou Wang

This study identifies ITCH as a key regulator of SARS-CoV-2 life cycle, showing it enhances virion assembly and secretion while suppressing spike protein cleavage, and demonstrates that ITCH inhibition reduces viral replication.

eLife · May 29, 2026Peer-reviewedMolecular Biology