Andrew S Pekosz

This study shows that sex differences in vaccine-induced neuraminidase (NA) antibody responses affect H5N1 virus dissemination in mice, with females showing better protection against lower respiratory tract infection.

This study compares the temperature-dependent replication of H5N1 genotypes B3.13 and D1.1 with H1N1pdm09 in human respiratory epithelial cells, finding differences in replication efficiency at different temperatures.

This study shows H5N1 influenza virus can be transmitted vertically through placental and mammary routes in pregnant mice, causing developmental impairments in offspring.

This study identifies an antigenically drifted and reassorted Influenza B virus, C.3.1/re, emerging late in the 2024-25 season, which is poorly neutralized by existing vaccines and may impact future vaccine strain selection.

This study identifies ITCH as a key regulator of SARS-CoV-2 life cycle, showing it enhances virion assembly and secretion while suppressing spike protein cleavage, and demonstrates that ITCH inhibition reduces viral replication.

This study investigates how IgG and IgA antibodies from serum are transported across respiratory epithelial cells and retain neutralizing activity against SARS-CoV-2 and influenza A virus.

This paper presents a continuous biomanufacturing platform for virus-like particle vaccines using multiple bioreactor configurations, demonstrating stable production and scalability.

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

The paper measures antibody responses to bovine A/H5N1 HA and NA in vaccinated and infected individuals, finding that A/H1N1 infection boosts neutralizing antibodies but vaccination and A/H3N2 infection do not.

This study identifies sex differences in long COVID sequelae in mice, showing that X-linked genes like Xist and Tlr7 contribute to persistent inflammation and cognitive impairments in females.

This study shows that the proton-activated chloride channel inhibits SARS-CoV-2 entry by blocking endosomal acidification and the cathepsin-dependent pathway.

This study identifies acute IFNα induction as the key mechanism by which the live measles vaccine is attenuated, revealing mutations in P/V/C and H genes responsible for this effect.

This paper presents a T-cell vaccine targeting conserved regions across Sarbecoviruses to provide cross-protection against evolving variants.

The paper identifies a mutation in the SARS-CoV-2 nucleocapsid protein that enhances viral infection by promoting dimer formation and altering virion structure.

This study evaluates antibody responses to a third dose of COVID-19 vaccine in kidney transplant recipients, finding reduced neutralizing antibodies and altered IgG subclass switching compared to healthy controls.

This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.

The paper studies SARS-CoV-2 variants from immunocompromised patients, finding altered syncytia formation, temperature-dependent replication, and antibody escape in some isolates.

This study shows that temperature affects mitochondrial structure and function, which in turn influences host cell outcomes during influenza A virus infection.

This study identifies clade-defining mutations in H1N1 hemagglutinin that improve viral fitness but reduce neutralization by vaccine-induced antibodies, revealing an evolutionary trade-off between replication and immune evasion.

The paper analyzes small RNA-seq data from SARS-CoV-1 and SARS-CoV-2 infected cells to identify novel viral short RNAs and their potential roles in infection.

This study demonstrates that antigen-display exosomes can induce strong neutralizing antibodies and protect against SARS-CoV-2 at nanogram levels of spike protein without adjuvant.