Molecular BiologyeLifePeer-reviewed
Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus
Qiwang Xiang, Camille Wouters, Peixi Chang…·Jiou Wang
This study identifies ITCH as a key regulator of SARS-CoV-2 life cycle, showing it enhances virion assembly and secretion while suppressing spike protein cleavage, and demonstrates that ITCH inhibition reduces viral replication.
DOI 10.7554/elife.105105