To mock or not: a comprehensive comparison of mock IP and DNA input for ChIP-seq
Jinrui Xu, Michelle M. Kudron, Alec Victorsen, Jiahao Gao, Haneen Ammouri, Fábio C. P. Navarro, Louis Gevirtzman, R Waterston, Kevin P. White, V Reinke, Mark Gerstein
This study compares mock IP and DNA input controls in ChIP-seq, showing that mock IP better removes spurious sites, while DNA input has unique advantages, and proposes combining both for improved binding site detection.
Nucleic Acids Research · Dec 18, 2020Peer-reviewedGenomics