DiffDomain enables identification of structurally reorganized topologically associating domains
Dunming Hua, Ming Gu, Xiao Zhang, Yanyi Du, Hangcheng Xie, Li Qi, Xiangjun Du, Zhidong Bai, Xiaopeng Zhu, Dechao Tian
DiffDomain identifies structurally reorganized TADs using Hi-C and single-cell Hi-C data, outperforming existing methods in accuracy and detecting new TAD subtypes.
Nature Communications · Jan 13, 2024Peer-reviewedBioinformatics