Xiao Zhang

DiffDomain-Spectrum identifies reorganized TADs from sparse aggregated scHi-C maps by analyzing eigenvalue spectra and comparing to a null model, showing higher sensitivity than existing methods.

DiffDomain identifies structurally reorganized TADs using Hi-C and single-cell Hi-C data, outperforming existing methods in accuracy and detecting new TAD subtypes.

The paper identifies two EBV variants in BALF2 associated with increased NPC risk through genome sequencing and association studies in China.