Xiaopeng Zhu

DiffDomain identifies structurally reorganized TADs using Hi-C and single-cell Hi-C data, outperforming existing methods in accuracy and detecting new TAD subtypes.

Nucleome Browser integrates heterogeneous 4D Nucleome data into an interactive platform for visualization and exploration across biological contexts.

This study uses Optical Replication Mapping to map human DNA replication initiation sites and finds that replication initiation is stochastic and not confined to specific origins.

MOCHI identifies heterogeneous interactome modules in the nucleus by clustering gene loci with frequent spatial contacts and shared transcription factor regulation across five cell types.