Dechao Tian

scStripe detects and quantifies chromatin stripes in single-cell Hi-C data, resolving cell-type-specific regulatory features and capturing genome-wide variation.

DiffDomain-Spectrum identifies reorganized TADs from sparse aggregated scHi-C maps by analyzing eigenvalue spectra and comparing to a null model, showing higher sensitivity than existing methods.

DiffDomain identifies structurally reorganized TADs using Hi-C and single-cell Hi-C data, outperforming existing methods in accuracy and detecting new TAD subtypes.

Nucleome Browser integrates heterogeneous 4D Nucleome data into an interactive platform for visualization and exploration across biological contexts.

MOCHI identifies heterogeneous interactome modules in the nucleus by clustering gene loci with frequent spatial contacts and shared transcription factor regulation across five cell types.