Author

Yanyi Du

Chinese Academy of SciencesORCID 0009-0006-3256-0733Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:Hi-C· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Dechao TianiD· 2 shared Xiao ZhangiD· 2 shared Dunming Hua· 1 shared Haishan ZhangiD· 1 shared Hangcheng Xie· 1 shared Jiadi ZhuiD· 1 shared Li Qi· 1 shared Ming Gu· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Dechao TianORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 17, 2026

DiffDomain-Spectrum identifies structurally reorganized TADs from sparse aggregated single-cell Hi-C contact maps

Jiadi Zhu, Haishan Zhang, Yanyi Du…·Dechao Tian

DiffDomain-Spectrum identifies reorganized TADs from sparse aggregated scHi-C maps by analyzing eigenvalue spectra and comparing to a null model, showing higher sensitivity than existing methods.

DOI 10.64898/2026.09.15.751728

Hi-Cstatistical model

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BioinformaticsNature CommunicationsPeer-reviewedJan 13, 2024

DiffDomain enables identification of structurally reorganized topologically associating domains

Dunming Hua, Ming Gu, Xiao Zhang…·Dechao Tian

DiffDomain identifies structurally reorganized TADs using Hi-C and single-cell Hi-C data, outperforming existing methods in accuracy and detecting new TAD subtypes.

25 citations

mouseHi-C

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