Ubiquitin ligase RNF126 exerts functions in lysosomal damage response and lysosomal homeostasis maintenance
Sophie Levantovsky, Bojana Kravić, Lizhen Cheng, Lukas Brecht, Hanna Tolle, Pinki Gahlot, Georg Kislinger, Kimberly Cramer, Regina Feederle, Benedikt Wefers, Wolfgang Wurst, Ralf Jungmann, Martina Schifferer, Hemmo H Meyer, Christian Behrends
This study identifies RNF126 as a ubiquitin ligase involved in lysosomal damage response and homeostasis, showing its recruitment to lysosomes and role in substrate ubiquitylation.
bioRxiv · Oct 19, 2026 · PreprintCell Biology