Martina Schifferer

This study identifies RNF126 as a ubiquitin ligase involved in lysosomal damage response and homeostasis, showing its recruitment to lysosomes and role in substrate ubiquitylation.

This study identifies cerebral microthrombi as focal sites of Cav-1-dependent BBB dysfunction after TBI, linking microvascular thrombosis to neuronal damage through transcytosis.

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

This study shows that DJ-1 deficiency impairs VMAT2 function and vesicle dynamics, leading to dopamine oxidation and α-synuclein pathology in Parkinson's disease neurons.

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

This study shows that TDP-43 and Tau directly interact, promoting co-condensation but reducing Tau fibril formation and seeding.

This study shows that TREM2 deficiency rescues synaptic integration and functional maturation of transplanted neurons in an inflammatory environment.

The paper identifies a retrograde transit filter in distal axons mediated by optineurin that regulates mitochondrial homeostasis, independent of PINK1 and parkin.

The paper shows that PINK1 precursor translation in neurons requires ER and endolysosome interaction, with DNAJB6 facilitating its transport to mitochondria for mitophagy.

This paper develops a real-time FRET-based system to monitor nanocarrier behavior and drug release at post-stroke microthrombi in vivo.

The paper introduces ATUM-Tomo, a hybrid method combining SEM and electron tomography for multi-scale ultrastructural analysis of cellular structures.

This paper develops a large animal model for demyelinating brain diseases using minipigs, demonstrating reversible and multimodally trackable lesions that mimic human pathology.

This study correlates spatial transcriptomics with electron microscopy to link microglial morphology with transcriptional signatures in mouse brain.

This study shows that loss of NPC1 in microglia increases phagocytic uptake and impairs lipid trafficking, leading to myelin accumulation and potential therapeutic implications.

The paper investigates myelin structural changes during development in mice and zebrafish, finding that myelin degeneration is resolved by microglia, while sheath retractions occur independently.

This paper analyzes juxtavascular microglia dynamics in mice and humans, showing their developmental migration along vessels and stabilization as astrocyte endfeet ensheath the vasculature.

The paper introduces ATUM-FIB, a hybrid microscopy technique that combines serial sectioning with FIB-SEM to enable targeted ultrastructural analysis at isotropic resolution.

The paper shows that single oligodendrocyte loss in mouse cortex triggers precise remyelination and cell replacement, preserving original myelin patterns while creating new internodes on unmyelinated axons.

The paper introduces a genetic iron-biomineralizing nanocompartment for multiplexed EM gene reporter imaging in mammalian cells.