Regina Feederle

Ubiquitin ligase RNF126 exerts functions in lysosomal damage response and lysosomal homeostasis maintenance

This study identifies RNF126 as a ubiquitin ligase involved in lysosomal damage response and homeostasis, showing its recruitment to lysosomes and role in substrate ubiquitylation.

RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids

This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.

PINK1 stabilizes RMDN3-VAPB interaction without altering the landscape of mito-ER contact sites

The paper investigates how PINK1 stabilizes the RMDN3-VAPB interaction at mitochondrial-ER contact sites during depolarization without changing the proteomic landscape.

Development of Motif-Specific Monoclonal Antibodies for Global Protein Citrullination Detection with Minimal Cross-Reactivity to Homocitrullination

This paper develops monoclonal antibodies specific for citrullination, showing high sensitivity and minimal cross-reactivity with homocitrullination.

Mitochondrial hitch-hiking of Mapt mRNA maintains Tau levels in axons

The paper identifies mitochondrial transport of MAPT mRNA via SYNJ2a/SYNJ2BP complex and shows its role in maintaining Tau levels and axonal growth in glutamatergic neurons.

The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain.

This study investigates the role of the CHCHD2-CHCHD10 protein complex in mitochondrial dysfunction and lipid homeostasis in mice, showing its importance in motor function and disease resistance.

Full-length Cryptochrome 1 in the outer segments of the retinal blue cone photoreceptors in humans and great apes suggests a role beyond transcriptional repression

The paper detects full-length CRY1 protein in blue cone photoreceptors of human and great ape retinas, suggesting non-clock functions and potential isoform diversity.

The nuclear speckles protein SRRM2 is a new therapeutic target molecule on the surface of cancer cells

The paper identifies SRRM2 as a surface-exposed cancer target and shows its utility in CAR-T cell therapy.

Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.