Ralf Jungmann

This study identifies RNF126 as a ubiquitin ligase involved in lysosomal damage response and homeostasis, showing its recruitment to lysosomes and role in substrate ubiquitylation.

This study resolves the debate on how ILK binds to β1 integrin by showing ILK is recruited via K2, not directly, using interdisciplinary methods.

This study uses DNA origami probes to investigate nanodomain organization and dynamics in plasma membranes by tracking their movement and interactions with nanodomains.

This study shows how Myo10 uses intrinsically disordered regions to bind different cargos, DCC and β1 integrin, through distinct mechanisms involving disorder-to-order transitions and fuzzy binding.

Combi-PAINT improves multiplexing in super-resolution microscopy by using combinatorial DNA barcoding, resolving 41 targets with high accuracy in under 30 minutes.

The paper introduces DIMMERs, miRNA-based circuits that enable precise, tunable control of transgene expression across cell types, improving gene therapy and research applications.

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.

This study visualizes individual sugars within glycans on the cell surface using angstrom-resolution fluorescence microscopy combined with metabolic labeling.

This study identifies key residues in Siglec-10 involved in ligand recognition and shows that antibody blockade can restore CAR-T cell cytotoxicity.

This study uses nanoscale DNA tracing to show that mitotic chromosomes form through self-organization via large, overlapping loops driven by Condensins.

This study shows that TREM2 deficiency rescues synaptic integration and functional maturation of transplanted neurons in an inflammatory environment.

This paper develops covalent aptamers that bind mouse monoclonal antibodies and uses them to create antibody-oligonucleotide conjugates for HIV detection and imaging.

This paper introduces a DNA origami-based nanopore that can adjust its size through molecular triggers, enabling size-selective transport of biomolecules.

This study uses super resolution microscopy to observe Arc high-order oligomers in excitatory synapses, revealing their role in AMPA receptor dynamics.

This paper introduces SUM-PAINT, a high-throughput imaging method for single-protein spatial resolution, and discovers a new synapse type through extensive multiprotein analysis.

The paper uses nanobodies and DNA-PAINT to show that Drosophila titin homologs Sallimus and Projectin are staggered in flight muscle sarcomeres.

The paper improves single molecule localization precision using patterned illumination in a conventional setup, achieving near twofold better precision than standard methods on DNA-origami structures.

This paper introduces a 3D particle averaging method for localization microscopy that improves signal-to-noise ratio and resolution without requiring a structural template.