Author

Hannah DiGiovanni

University of Michigan

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Evolutionary Biology· 1

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Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

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David GinsburgiD· 1 shared David R. Siemieniak· 1 shared Laura M. HaynesiD· 1 shared Matthew L. HoldingiD· 1 shared

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1 shared paperEvolutionary Biology

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1 paper

Recent·Most cited

High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases

Laura M. Haynes, Matthew L. Holding, Hannah DiGiovanni, David R. Siemieniak, David Ginsburg

This study uses deep mutational scanning to analyze PAI-1's inhibitory interactions with three serine proteases, revealing sequence determinants and evolutionary conservation of specificity.

Protein Science · Mar 18, 2025Peer-reviewedEvolutionary Biology