Matthew L. Holding

This study maps the mutational landscape of streptokinase (SK) from Group C Streptococcus to identify amino acid substitutions affecting its binding to human plasminogen.

This study examines snake venom fluidic properties and develops non-toxic mimics to model venom flow for biomedical and evolutionary research.

The paper identifies 21 human 'lonely genes' in large gene deserts, finds they are mostly cell adhesion molecules, and suggests they are structurally isolated and vulnerable in brain development.

This study uses deep mutational scanning to analyze how PAI-1 variants affect its latency transition and uPA inhibition, showing that thermodynamic stability and evolution shape its function.

The paper studies gene duplication in SERPINA genes across vertebrates and shows that duplicated paralogs in rodents can inhibit snake venom proteases, suggesting adaptive functional variation.

This study investigates venom resistance in Monodelphis domestica, finding it resists venom-induced coagulation disruption and has unique von Willebrand Factor behavior under flow.

This study uses deep mutational scanning to analyze PAI-1's inhibitory interactions with three serine proteases, revealing sequence determinants and evolutionary conservation of specificity.

This study uses microsatellite markers to analyze genetic diversity in Chiricahua Leopard Frogs, revealing genetic bottlenecks and rapid diversity loss in managed populations.

This study identifies PROX1 and CHD7 as regulators of LDL uptake, with PROX1 directly enhancing LDLR expression and CHD7 acting through an LDLR-independent mechanism.

This study uses trio binning to assemble genomes of two woodrat species, revealing expanded and novel cytochrome p450 gene islands linked to dietary adaptation to toxic plants.