Laura M. Haynes

This study maps the mutational landscape of streptokinase (SK) from Group C Streptococcus to identify amino acid substitutions affecting its binding to human plasminogen.

This study uses deep mutational scanning to analyze how PAI-1 variants affect its latency transition and uPA inhibition, showing that thermodynamic stability and evolution shape its function.

The paper studies gene duplication in SERPINA genes across vertebrates and shows that duplicated paralogs in rodents can inhibit snake venom proteases, suggesting adaptive functional variation.

This study investigates venom resistance in Monodelphis domestica, finding it resists venom-induced coagulation disruption and has unique von Willebrand Factor behavior under flow.

This study uses deep mutational scanning to analyze PAI-1's inhibitory interactions with three serine proteases, revealing sequence determinants and evolutionary conservation of specificity.